This is something that I encountered before but it cropped up again this morning and I thought it was time to get it on ‘paper’.

To allow for complete control of the application configuration, GO! Sync Mapbook uses reflection to load all of it’s components. This seems to cause a problem in Vista with machines that have Data Execution Prevention (DEP) running. The ActiveX controls that makeup ArcGIS Engine do not load properly.

There is a pretty good article here that shows how to turn it off completely.

I used the following command line to fix it:

bcdedit /set nx AlwaysOff

You need to run the command prompt as Administrator for it to work.